In the post-genomic era of medicine, histopathological assessment of colorectal carcinoma specimens plays the key role in the comprehensive management of patients with colorectal cancer. Adequate specimen handling and dissection is a crucial step in obtaining a precise and accurate pathohistologic report. Microscopic analysis must give information on: histological tumour type and differentiation, maximum extent of local invasion (pT stage), grade of tumour regression following pre-operative (neoadjuvant) therapy, resection margins (longitudinal and circumferential margins), lymph node status, venous invasion, MSI status and other abnormal findings. Latest ESMO consensus guidelines for the management of patients with metastatic colorectal cancer emphasize the pathologist’ role in this process. Recently defined molecular subtypes of colorectal cancer will hopefully serve as the basis for future trials.
展开▼
